CV

Education

Ph.D. in Bioanalytical and Physical Chemistry
- University of the Pacific, Stockton, CA, USA
- Aug. 2016 – May 2021
M.S. in Environmental Engineering
- University of the Pacific, Stockton, CA, USA
- Sep. 2012 – May 2014
B.S. in Ecology
- University of Science and Technology Beijing, Beijing, China
- Sep. 2008 – Jun. 2012

Work Experience

Scientist – Senior Scientist, Bristol Myers Squibb, CA, USA, Oct. 2021 – Present
- Leading mass spectrometry characterization and high-resolution Carbene Footprinting for epitope/paratope mapping to support biologics, ADCs, and cell therapy pipelines.
- Co-inventor of anti-LRRC15 antibodies and antibody-drug conjugates (ADCs) (granted US patent / WIPO international patent applications).
- Spearheaded deep learning workflows and foundation model fine-tuning (e.g. ST-Tahoe single-cell perturbation) and automated LC-MS data analysis pipelines.
- Mentored data science and bioinformatics interns (Recipient of the CABS Mentor Impact Award).
Research Assistant, University of the Pacific, CA, USA, Aug. 2016 – Aug. 2021
- Investigated structural and energetic properties of peptoids/peptides using advanced MS and computational modeling.
- Developed computational workflows for peptide/peptoid characterization; contributed to 3 peer-reviewed publications.
- Mentored 25+ students in peptide synthesis, MS, and molecular modeling; several mentees pursued advanced degrees.

Skills

Analytical Techniques
- Carbene footprinting for epitope/paratope mapping, Peptide Mapping, Glycan Profiling, Native MS, Intact/Subunit Mass Analysis
Instrumentation
- Orbitrap Fusion Lumos, Exactive Plus EMR, ZenoTOF 7600, TripleQuad 7500, timsTOF Pro2, 6530B QTOF, 6230B TOF
- Acquity M Class, 1260/1290 Infinity II, Ultimate 3000, NanoElute2
- Maurice System
Computational & Data Analysis
- Analytical Software: Skyline, Xcalibur, Sciex OS, Compass
- Molecular Modeling: Gaussian, Orca, GaussView, VMD, Maestro, PyMOL
- Programming & Data Science: Python, Bash, PyTorch, PyTorch Lightning, Pandas, Scikit-learn
- ML Models & Techniques: Deep Learning, Foundation Models (ST-Tahoe, Boltz-2, AlphaGenome), Fine-Tuning, Representation Learning
- Platforms & MLOps: Google Cloud Platform (GCP), AWS Bedrock, Domino Data Lab, Docker, uv, pip, Git, Weights & Biases (W&B)

Awards and Fellowships

Mentor Impact Award, Chinese American Biopharmaceutical Society (CABS), Sep. 2026
- Recognized for mentoring interns in machine learning and bioinformatics pipelines within the CABS Summer Internship Program.
Poster Award at Science Festival, Bristol Myers Squibb, Oct. 2023
- Selected for best poster presentation.
PCSP Graduate Seminarian of the Year, University of the Pacific, Nov. 2020
- Selected for outstanding research seminar presentation.
John H. Shinkai Endowed Graduate Student Scholarship, University of the Pacific, Jun. 2017 & Jun. 2020
- Awarded for excellence in research and academic accomplishment.
PCSP College of the Pacific Dean’s Travel Award, University of the Pacific, Jun. 2019
- Competitive travel grant for conference presentation.

Publications

Patents

Anti-LRRC15 Antibody Drug Conjugates

Sayumi Yamazoe, Sonia G. Tanlimco, Lore Florin, Philip M. Vitorino, Qinqin Cheng, Christine H. Tan, Yuntao Zhang, Sunitha Bachawal, Hok Yee Chan, Winse Hong Morishige, Andrew W. Drake, Deanne M. Lathers, Jaimee C. Wong. (2026). "Anti-LRRC15 Antibody Drug Conjugates." WIPO Patent Publication No. WO/2026/112472 A1 (U.S. Patent Application No. US 2026/0144884 A1; U.S. Notice of Allowance Issued).

Anti-LRRC15 Antibodies and Uses Thereof

Bristol-Myers Squibb Company (Co-inventor: Yuntao Zhang). (2026). "Anti-LRRC15 Antibodies and Uses Thereof." WIPO Patent Publication No. WO/2026/112469 A1 (U.S. Patent Application No. US 2026/0144885 A1).

Journal Articles

Chirality Effects on the Intrinsic Acidity of Isomeric Tripeptides Containing a D/L-Cysteine on the N-terminus: CAA and dCAA

Shiyuan Wang, Zachary Buen, Kimberlyann R. Harvey, Yuntao Zhang, Jianhua Ren. (2025). "Chirality effects on the intrinsic acidity of isomeric tripeptides containing a D/L-Cysteine on the N-terminus: CAA and dCAA." International Journal of Mass Spectrometry, 514, 117472. https://doi.org/10.1016/j.ijms.2025.117472

Subtle chirality effects of a D/l-Cysteine on the intrinsic acidity and conformation of isomeric tripeptides ACA and AdCA

Yuntao Zhang, Zachary Buen, Michael D. Browne, Yadwinder S. Mann, Jianhua Ren. (2021). "Subtle chirality effects of a D/l-Cysteine on the intrinsic acidity and conformation of isomeric tripeptides ACA and AdCA." International Journal of Mass Spectrometry, 469, 116685. https://doi.org/10.1016/j.ijms.2021.116685

Mass spectrometry studies of the fragmentation patterns and mechanisms of protonated peptoids

Jianhua Ren, Yuan Tian, Ekram Hossain, Joshua S Ho, Yadwinder S Mann, Yuntao Zhang, Michael D Browne, Michael D Connolly, Ronald N Zuckermann. (2020). "Mass spectrometry studies of the fragmentation patterns and mechanisms of protonated peptoids." Biopolymers, 111(7):e23358. https://doi.org/10.1002/bip.23358

Characterization of protonated AcAlaDab and AcDabAla by IRMPD spectroscopy and molecular modeling

Patrick Batoon, Yuntao Zhang, Giel Berden, Jos Oomens, Jianhua Ren. (2019). "Characterization of protonated AcAlaDab and AcDabAla by IRMPD spectroscopy and molecular modeling." International Journal of Mass Spectrometry, 444, 116178. https://doi.org/10.1016/j.ijms.2019.116178

Synthesis and Mass Spectrometry Analysis of Oligo-peptoids

Jianhua Ren, Yadwinder S Mann, Yuntao Zhang, Michael D Browne. (2018). "Synthesis and Mass Spectrometry Analysis of Oligo-peptoids." J Vis Exp, (132):56652. https://doi.org/10.3791/56652

Talks

Chirality Induced Conformational and Thermochemical Changes in Cysteine Polyalanine Peptides

January 18, 2020

Talk at Conference on Ion Chemistry and Mass Spectrometry, UCLA, Jan. 2020, Lake Arrowhead, CA, USA

How Can D-Amino Acids Influence the Conformations and the Acidities of Oligopeptides?

January 19, 2019

Talk at Conference on Ion Chemistry and Mass Spectrometry, UCLA, Jan. 2019, Lake Arrowhead, CA, USA

Service and Leadership

Mentor, CABS 2026 Data Science Summer Internship Program, Chinese American Biopharmaceutical Society (CABS), Sep. 2026
Peer Reviewer for:
- ACS Biomaterials Science & Engineering
- ACS Omega
- Inorganica Chimica Acta
- RSC Advances
Active member of the American Society for Mass Spectrometry (ASMS) since 2017

Yuntao Zhang

CV