Co-inventor on Two U.S. Provisional Patent Applications
Co-inventor on two pending U.S. provisional patent applications. Filed via Bristol Myers Squibb. (Details are confidential until publication).
CV
Education
- Ph.D. in Bioanalytical and Physical Chemistry
- University of the Pacific, Stockton, CA, USA
- Aug. 2016 – May 2021
- M.S. in Environmental Engineering
- University of the Pacific, Stockton, CA, USA
- Sep. 2012 – May 2014
- B.S. in Ecology
- University of Science and Technology Beijing, Beijing, China
- Sep. 2008 – Jun. 2012
Work Experience
- Scientist – Senior Scientist, Bristol Myers Squibb, CA, USA, Oct. 2021 – Present
- Lead implementation of carbene footprinting for high-resolution epitope/paratope mapping.
- Improved carbene footprinting workflow throughput by threefold, accelerating key program advancement.
- Characterized antibody biologics for multispecific, ADC, and CAR-T programs, directly informing strategic decisions.
- Developed and optimized novel LC-MS methods across multiple platforms to solve complex analytical challenges.
- Trained 20+ scientists in advanced MS techniques; managed fleet services and operations as department champion.
- Research Assistant, University of the Pacific, CA, USA, Aug. 2016 – Aug. 2021
- Investigated structural and energetic properties of peptoids/peptides using advanced MS and computational modeling.
- Developed computational workflows for peptide/peptoid characterization; contributed to 3 peer-reviewed publications.
- Mentored 25+ students in peptide synthesis, MS, and molecular modeling; several mentees pursued advanced degrees.
Skills
- Analytical Techniques
- Carbene foootprinting for epitope/paratope mapping, Peptide Mapping, Glycan Profiling, Native MS, Intact/Subunit Mass Analysis
- Instrumentation
- Orbitrap Fusion Lumos, Exactive Plus EMR, ZenoTOF 7600, TripleQuad 7500, timsTOF Pro2, 6530B QTOF, 6230B TOF
- Acquity M Class, 1260/1290 Infinity II, Ultimate 3000, NanoElute2
- Maurice System
- Computational & Data Analysis
- Analytical Software: Byos, Skyline, Xcalibur, Sciex OS, Compass
- Molecular Modeling: Gaussian, Orca, GaussView, VMD, Maestro, PyMOL
- Programming & Data Science: Python, Bash, PyTorch, PyTorch Lightning, Pandas, Scikit-learn
- ML Models & Techniques: Deep Learning, Foundation Models (ST-Tahoe, Boltz-2, AlphaGenome), Fine-Tuning, Representation Learning
- Platforms & MLOps: Google Cloud Platform (GCP), AWS Bedrock, Domino Data Lab, Docker,
uv,pip, Git, Weights & Biases (W&B)
Publications
Chirality Effects on the Intrinsic Acidity of Isomeric Tripeptides Containing a D/L-Cysteine on the N-terminus: CAA and dCAA
Shiyuan Wang, Zachary Buen, Kimberlyann R. Harvey, Yuntao Zhang, Jianhua Ren. (2025). "Chirality effects on the intrinsic acidity of isomeric tripeptides containing a D/L-Cysteine on the N-terminus: CAA and dCAA." International Journal of Mass Spectrometry, 514, 117472. https://doi.org/10.1016/j.ijms.2025.117472
Subtle chirality effects of a D/l-Cysteine on the intrinsic acidity and conformation of isomeric tripeptides ACA and AdCA
Yuntao Zhang, Zachary Buen, Michael D. Browne, Yadwinder S. Mann, Jianhua Ren. (2021). "Subtle chirality effects of a D/l-Cysteine on the intrinsic acidity and conformation of isomeric tripeptides ACA and AdCA." International Journal of Mass Spectrometry, 469, 116685. https://doi.org/10.1016/j.ijms.2021.116685
Mass spectrometry studies of the fragmentation patterns and mechanisms of protonated peptoids
Jianhua Ren, Yuan Tian, Ekram Hossain, Joshua S Ho, Yadwinder S Mann, Yuntao Zhang, Michael D Browne, Michael D Connolly, Ronald N Zuckermann. (2020). "Mass spectrometry studies of the fragmentation patterns and mechanisms of protonated peptoids." Biopolymers, 111(7):e23358. https://doi.org/10.1002/bip.23358
Characterization of protonated AcAlaDab and AcDabAla by IRMPD spectroscopy and molecular modeling
Patrick Batoon, Yuntao Zhang, Giel Berden, Jos Oomens, Jianhua Ren. (2019). "Characterization of protonated AcAlaDab and AcDabAla by IRMPD spectroscopy and molecular modeling." International Journal of Mass Spectrometry, 444, 116178. https://doi.org/10.1016/j.ijms.2019.116178
Synthesis and Mass Spectrometry Analysis of Oligo-peptoids
Jianhua Ren, Yadwinder S Mann, Yuntao Zhang, Michael D Browne. (2018). "Synthesis and Mass Spectrometry Analysis of Oligo-peptoids." J Vis Exp, (132):56652. https://doi.org/10.3791/56652
Talks
Chirality Induced Conformational and Thermochemical Changes in Cysteine Polyalanine Peptides
Talk at Conference on Ion Chemistry and Mass Spectrometry, UCLA, Jan. 2020, Lake Arrowhead, CA, USA
How Can D-Amino Acids Influence the Conformations and the Acidities of Oligopeptides?
Talk at Conference on Ion Chemistry and Mass Spectrometry, UCLA, Jan. 2019, Lake Arrowhead, CA, USA
Teaching
Service and Leadership
- Peer Reviewer for:
- ACS Biomaterials Science & Engineering
- ACS Omega
- Inorganica Chimica Acta
- RSC Advances
- Active member of the American Society for Mass Spectrometry (ASMS) since 2017